Air believed to be one of the major causes

 Air pollutants generated from traffic and
industrial plants are believed to be one of the major causes of DNA damage in
living species. As a result of rapid urbanization, air pollution and
environmental quality deterioration have been affecting our daily lives as well
as the nature.    

Several experimental
studies have reported that lead has a moderate genotoxic potential.

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In a study conducted by
Valverde and colleagues ,(26) a lead inhalation model in mice was used to
detect the induction of genotoxic damage as single-strand breaks and
alkali-labile sites in several mouse organs (nasal epithelial cells, lung,
whole blood, liver, kidney, bone marrow, brain, and testes), assessed by the
comet assay. Following single and subsequent inhalations, differences were
found among the organs studied. A positive induction of DNA damage in the liver
and the lung after a single inhalation was observed. The response was positive
in all organs, except the testicle, in subsequent inhalations. DNA damage
induction over time varied for each organ. The brain and bone marrow showed the
highest damage induced. Differences in DNA damage occurred in organs when lead
was administered acutely or sub-chronically.

Our  study 
revealed  a  significant 
increase  in  the 
blood  lead  level of 
study  group  and controls ( p value 0.000). The mean pb in
our study was 18.76±8.8  and controls
mean pb was 12±3.5 as compared to study in Islamabad that was carried out in
2005 in which blood lead levels of wardens were 27.27 ±4.04 and a similar study
on traffic wardens in Karachi  indicated
a value of lead in wardens  of 47.7±15.8.micrograms
/dl.Another study in Alexandrria Eygpt reported that their  traffic constables had a higher blood lead
level than our study  (27).  

Blood lead levels were
analyzed in Nigerian traffic wardens, comprising sixty from Lagos , thirteen
from the sparsely populated university town of Ile-Ife and a control group of
twenty-four subjects . The mean lead level in Lagos wardens was 18.1 ± 6.4 ?g/dl,
which was significantly higher than the level of 10.2 ± 2.7 ?g/dl in Ife
wardens and 12.9 ± 7.0 ?g/dl obtained in the controls (P


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