Flavonoids to reduce inflammatory response, to inhibit hepatic apoptosis

Flavonoids are low molecular weight compounds
composed of a three-ring structure with various substitutions (Middleton et
al., 2000). Flavonoids known to be polyphenolic
compounds and are classified into flavonols, flavones, flavanones, isoflavones
with different chemical structures. Flavonoids used
as antiviral, antiallergic, antiplatelet, antitumor, antioxidant, and
anti-inflammatory agents (Lago et al., 2014). The methanol extract of Ficus
pumila showed the contents
of rutin, apigenin and luteolin in the HPLC analysis and has anti-inflammatory and analgesic
activities (Liao et al., 2012). Vernonia polyanthes Less. (Asteraceae)
the ethyl acetate extracts of V. polyanthes leaves. It contains rutin, luteolin and apigenin
were identified by HPLC-UV/DAD analysis. It has topical anti-inflammatory
activity (Rodrigues et al., 2016). HPLC
analysis showed that the rutin present in the methanolic
extract of Emblica officinalis and
has anti-inflammatory and pancreas protective
effects (Aruna et al., 2014). Scutia
buxifolia Reissek (Rhamnaceae) HPLC analysis has detected quercetin and rutin compounds. It has topical anti-inflammatory
action (Boligon et al., 2017). Apigenin possesses
many pharmacological effects, including anti-inflammatory,
anticancer, antioxidant and antiviral activities. It inhibits foot-and-mouth
disease virus infection in the viral post-entry stage (Qian et al., 2015). Many herbal flavonoids, compounds play major role in curing inflammation such as Acacetin, it blocks the Kv1.3
channel and inhibits human T cell activation (Zhao et al., 2014). Chrysin, act as an anti-inflammatory
and antioxidant agent. It also showed
anti-asthmatic potential (Wadibhasme et al., 2011). Wogonin,
existing monoflavonoid and it has antiinflammatory,
anti-cancer, anti-viral and neuroprotective actions (Tai et al., 2005). Baicalein, have the ability to reduce inflammatory
response, to inhibit hepatic apoptosis (Liu et al., 2015).


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